Product Description PROFHILO® is based on stabilsed
hybrid cooperative complex, and it is the pioneer of
BIOREMODELLING. It is the first product developed with
NAHYCO® technology, a unique and innovative thermal production
process, 100% free of chemical stabilising agents, patented by
IBSA.PROFHILO® is indicated for TISSUE REMODELING AND
IMPROVEMENT IN SKIN LAXITY of face, neck, and décolletage.
PROFHILO® promotes the restoration of firmness, tone and
elasticity of tissues in an authentic way, leading to a DYNAMIC
MULTILEVEL REMODELLING of the extracellular matrix in terms of
elasticity and support, as well as maintaining and promoting the
normal vitality of Fibroblasts, Keratinocytes and Adipocytes.Unique
characteristics of the product are: natural HA with a duration
comparable to a low cross-linked gel, high HA concentration
(64mg/2ml), high manageability, extensive spreadability, low
viscosity, no BDDE or other chemical agents, and low inflammatory
response.(P.S: the package way of Profhilo has some difference
sometimes .)Profhilo® is not a dermal filler or
biorevitaliser - Profhilo® has opened up a new injectable
category - bioremodeling.Thermal cross-linking changes the
character and behavior of the HA resulting in the formation of
co-operative hybrid complexes which modulate the tissues. This is
also the explanation for the different biological behavior with
respect to H-HA and L-HA alone. One of the main advantages is
longevity. Hybrid cooperative complexes have proven to be very
stable with natural hyaluronidase (BTH) digestion when compared to
H-HA, widely used in biorevitalisation products, or L-HA alone
resulting in the long-lasting release and the dual action of the
two HA components. This dual action is ideal for remodeling skin
laxity.How does Profhilo work? Profhilo is the first
BDDE-free injectable Hyaluronic Acid for hydrating skin and
treating skin laxity. With one of the highest concentrations of HA
in the market (64mg/2cc), the stabilised HA lasts in the skin for
about 28 days.Profhilo works because of 2 types of hyaluronic acid:
L-HA and H-HA. This hybrid of HA allows hyaluronic acid to be
released slowly and lasts longer allowing bioremodeling to take
place.L-HA as a hybrid complex is released slowly and hydrates your
skin, providing the Hydro effect.H-HA provides a stable HA
architecture in the dermis that allows volumetric replacement,
giving the Lift effect.During this time, the slow release of
HA kickstarts stimulation of 4 different types of collagen and
elastin.Histologically, the expression levels of type I and type
III collagen and type IV and VII collagen in keratinocytes are
increased. Profhilo is Not a Filler or
SkinboosterProfilo treatment is considered a bioremodelling
therapy. This unique stabilized hybrid cooperative HA complex has
different biological properties when compared to monotherapy with
either High or Low molecular weight HAs. The resistance to
enzymatic degradation, slow release action and biocompatibility
properties makes it different from the standard HAs in today's
market. The slow release action of Profhilo treatment provides
hydration at the epidermal layer and enhances volume within the
dermal architecture. There is an up-regulation of the 4 main
types of collagen. There is an increased expression of type I and
III collagen in fibroblasts and type IV and VII in keratinocytes.
In addition, elastin and natural HAs within the skin are
stimulated. This multimodal effect increases hydration, elasticity
and lifting effect of the skin.Can Profhilo be used for other
Indications? The current indication is for the lower
two-thirds of the face and neck for skin rejuvenation. There
are case studies of doctors using Profhilo either as monotherapy or
combination therapy for atrophic scars, facial acne scars and post
surgical scars on the lower limbs. There are also preliminary
reports of Profhilo as a complementary therapy for the management
of atopic dermatitis. These results although encouraging are
considered off-label for the moment.Can I Still Do Profhilo After I
Had A Filler? A consultation is necessary before any treatment. We
would need to explore what type Filler injection you had,
and when it was given. Although Profhilo is biocompatible,
BDDE-free and does not contain chemical cross-linked agents, we are
of the opinion that there must be a gap of at least 4
weeks from your last filler treatment.Here are 5 reasons why
you should try Profhilo: 1.Collagen and elastin bio-remodelling in
the skin Profhilo tightens, hydrates, and rejuvenates
the skin by kickstarting 4 different types of collagen and elastin.
It also enhances the renewal of cells.2.Lesser injection
pointsUnlike traditional injection methods where there is a series
of small jabs all over the face, Profhilo involves fewer injections
- just five on each side of the face.3.It works from deep within &
targets different skin layersProfhilo uses both high and low
molecular-weight hyaluronic acid
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